Mechanism of ATP-sensitive K Channel Inhibition by Sulfhydryl Modification
نویسندگان
چکیده
منابع مشابه
Mechanism of ATP-sensitive K Channel Inhibition by Sulfhydryl Modification
ATP-sensitive potassium (KATP) channels are reversibly inhibited by intracellular ATP. Agents that interact with sulfhydryl moieties produce an irreversible inhibition of KATP channel activity when applied to the intracellular membrane surface. ATP appears to protect against this effect, suggesting that the cysteine residue with which thiol reagents interact may either lie within the ATP-bindin...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1998
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.112.3.325